产品编号：I163902

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	I163902
名称:	iCRT-14-d5
别名:	5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-(phenyl-d5)-2,4-thiazolidinedione; iCRT 14-d5; iCRT14-d5;
CAS号:	1795144-12-5
参考CAS号:	类似: 677331-12-3
分子式:	C₂₁H₁₂D₅N₃O₂S
分子量:	380.47
种类:	Building Blocks; Isotopic Labeled Analogues;
应用:	A labelled potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
参考文献	Gonsalves, F.C. et al.: Proc. Natl. Acad. Sci. USA, 108, 5954 (2011); Watanabe, K. et al.: Proc. Natl. Acad. Sci. USA, 108, 5929 (2011);