产品编号：I120050
产品规格：5mg
产品价格：面议
| 标准品编号: | I120050 |
| 名称: | I-BET 151 |
| 别名: | 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-Imidazo[4,5-c]quinolin-2-one; |
| CAS号: | 1300031-49-5 |
| 分子式: | C₂₃H₂₁N₅O₃ |
| 外观: | 白色固体 |
| 熔点: | >262°C (dec.) |
| 分子量: | 415.44 |
| 储存: | 冰箱 |
| 溶解度: | DMSO (Slightly), Methanol (Slightly) |
| 种类: | Research Tools; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | I-BET 151 is part of a novel series of quinoline isoxazole BET family bromodomain inhibitors, a family of four proteins that selectively bind to aceylated lysine residues in histone. I-BET 151 play key roles in many cellular processes, including anti-inflammatory gene expression, mitosis, and viral/host interaction by controlling the conformation of histone acetylation -dependent chromatin complexes. Studies have shown that I-BET 151 increased ApoA1 expression within the nanomolar range in human hepatic cell line HepG2. The upregulation by I-BET 151 suggested potential anti-inflammatory activities upon administration. |
| 危险品: | Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package |
| 参考文献 | |
