产品编号：H949955

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	H949955
名称:	2-Hydroxy Nevirapine 2-O-β-D-Glucuronide
别名:	11-Cyclopropyl-6,11-dihydro-4-methyl-6-oxo-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-2-yl β-D-Glucopyranosiduronic Acid
CAS号:	245500-91-8
分子式:	C₂₁H₂₂N₄O₈
分子量:	458.42
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	2-Hydroxy Nevirapine 2-O-β-D-Glucuronide is the O-glucuronide derivative of 2-Hydroxy Nevirapine (H948625); a metabolite of Nevirapine (N391275) which is a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Also antiviral.
参考文献	Hargrave, K.D., et al.: J. Med. Chem., 34, 2231 (1991); Cheeseman, S.H., et al.: Antimicrob. Agents Chemother., 37, 178 (1993); Guay, L.A., et al.: Lancet, 354, 795 (1999); Erickson, D.A., et al.: Drug Metab. Dispos., 27, 1488 (1999); Riska, P.S., et al.: Drug Metab. Dispos., 27, 1434 (1999)