产品编号：H949698

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	H949698
名称:	rac-N-​[(1R)​-​2-​Hydroxy-​3-​methyl-​1-​(2-​methylpropyl)​-​3-​buten-​1-​yl]​-​carbamic Acid 1,​1-​Dimethylethyl Ester
别名:	rac-t-Butyl ((4R)-3-Hydroxy-2,6-dimethylhept-1-en-4-yl)carbamate
分子式:	C₁₄H₂₇NO₃
外观:	Solid
分子量:	257.37
种类:	Standards; Chiral Molecules;
应用:	rac-N-​[(1R)​-​2-​Hydroxy-​3-​methyl-​1-​(2-​methylpropyl)​-​3-​buten-​1-​yl]​-​carbamic Acid 1,​1-​Dimethylethyl Ester is an intermediate in synthesizing (R)-2-Amino-4-methyl-1-((S)-2-methyloxiran-2-yl)pentan-1-one Trifluoroacetate Salt (A605100), an impurity of carfilzomib (C183460). Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
参考文献	Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012)