产品编号：H831225
产品规格：10mg
产品价格：面议
| 标准品编号: | H831225 |
| 名称: | N-Hydroxy-N’-(4-butyl-2-methylphenyl)formamidine |
| 别名: | HET-0016 |
| CAS号: | 339068-25-6 |
| 分子式: | C₁₂H₁₈N₂O |
| 外观: | 白色至淡黄色固体 |
| 熔点: | 138-140°C |
| 分子量: | 206.28 |
| 储存: | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度: | Chloroform (Slightly), Ethanol (Slightly) |
| 种类: | Research Tools; Enzyme Activators and Inhibitors; |
| 应用: | HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE acting via inhibition of CYP4A (IC50=8.9nM (human), 35nM (rat renal microsome). IC50 cyclooxygenase=2.3uM. IC50 for other CYP’s: CYP2C9-3.3uM, CYP2D6=83.9 uM, CYP3A4=71uM. It inhibits cerebrovascular constriction induced by Ca2+ or archidonate and inhibits angiogenesis and endothelial cell sprouting in various models. Displays protective effect on brain damage after temporary focal ischemia (at 10mg/Kg). |
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