产品编号：H719013

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	H719013
名称:	6-Hydroxy-20,21-epoxy Eplerenone 20-O-Ethyl Enol Ether
别名:	(3R,4a'S,4b'R,5a'R,6a'S,9a'S,9b'R,10'S,11'R)-Methyl 1-ethoxy-11'-hydroxy-4a',6a'-dimethyl-2'-oxo-3',4',4a',5a',6',6a',8',9',9a',9b',10',11'-dodecahydro-2'H-2,6-dioxaspiro[bicyclo[3.1.0]hexane-3,7'-cyclopenta[1,2]phenanthro[4,4a-b]oxirene]-10'-carboxylate
分子式:	C₂₆H₃₄O₈
外观:	白色固体
分子量:	474.54
溶解度:	Chloroform; Methanol
种类:	Standards; Steroids; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	6-Hydroxy-20,21-epoxy Eplerenone 20-O-Ethyl Enol Ether is an intermediate in synthesizing 6β,21-Dihydroxy-Eplerenone (E588750). Eplerenone (E588775) is a selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.
参考文献	de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987); Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001); Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004); Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005)