产品编号：G797400

产品规格：10mg

产品价格：面议

---

产品详情

标准品编号:	G797400
名称:	GSI-953
别名:	5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide; Begacestat; GSI 953;
CAS号:	769169-27-9
分子式:	C₉H₈ClF₆NO₃S₂
外观:	白色固体
熔点:	153-155°C
分子量:	391.74
储存:	-20°C Freezer
溶解度:	DMSO, Methanol
种类:	Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Begacestat (GSI-953) is a selective β-secretase inhibitor that selectively inhibits cleavage of APP over Notch. GSI-953 is used for treating diseases such as cancer in relation to prevention of intestinal secretory metaplasia.
参考文献	van Es., et al.: Nature, 435, 959 (2005), Morohashi., et al.: J. Biol. Chem., 281, 1467 (2006), O'Neil., et al.: Neoplasia, 107, 781 (2006), Mayer, et al.: J. Med. Chem., 51, 7348 (2008), Martone, et al.: J. Pharmacol. Exp. Ther., 331, 598 (2009),