产品编号：H011600

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	H011600
名称:	HA130
别名:	B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]boronic Acid;
CAS号:	1229652-21-4
分子式:	C₂₄H₁₉BFNO₅S
分子量:	463.29
种类:	Research Tools;
应用:	HA130 is a selective boronic acid-based inhibitor of autotaxin. Studies show that adminstration of HA130 in mice results in rapid decrease of the lipid mediator lysophosphatidic acid (LPA) in the circulation. These findings suggest that HA 150 may provide useful therapeutic strategy in treating disorders associated with vascular development, inflammation, fibrotic disease, and tumor progression.
参考文献	Albers, H.M.H.G. et al.: Proc. Natl. Acad Sci. USA, 107, 7257 (2010); Albers, H.M.H.G. et al.: J. Med. Chem., 53, 4958 (2010);