产品编号：H011520
产品规格：2mg
产品价格：面议
| 标准品编号: | H011520 |
| 名称: | H-1152 Dihydrochloride |
| 别名: | 5-[[(2S)-Hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methylisoquinoline Hydrochloride; (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]Homopiperazine Dihydrochloride; |
| CAS号: | 871543-07-6 |
| 参考CAS号: | Free Base: 451462-58-1 |
| 分子式: | C₁₆H₂₃Cl₂N₃O₂S |
| 外观: | 白色至白色固体 |
| 熔点: | 182-184°C |
| 分子量: | 392.34 |
| 储存: | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| 溶解度: | Methanol, Water |
| 稳定性: | Hygroscopic |
| 种类: | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27 mMfor PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells. |
| 参考文献 | |
