产品编号：G797615
产品规格：2.5mg
产品价格：面议
| 标准品编号: | G797615 |
| 名称: | GSK 1702934A |
| 别名: | 1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one |
| CAS号: | 924377-85-5 |
| 分子式: | C₂₂H₂₅N₃O₂S |
| 分子量: | 395.52 |
| 种类: | Standards; Enzyme Activators and Inhibitors; |
| 应用: | GSK 1702934A is a potent and selective TRPC3/6 activator (EC50 = 80 and 440 nM for TRPC3 and 6, respectively). Exhibits no activity at TRPV4, TRPA1, M1, M4, CaV1.2, hERG, NaV1.5, or CXCR5 receptors at concentrations <10 μmol/L. Induces TRPC3/6-currents in HEK293 cells transduced with recombinant human TRPC3/6. Directly activates TRPC channels through by-passing phospholipase-C signaling. Also induces calcium signals in HEK-TRPC6 cells (pEC50 = 6.6). |
| 参考文献 | |
