产品编号：H288903

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	H288903
名称:	Heraclenin
别名:	9-[[(2R)-3,3-Dimethyl-2-oxiranyl]methoxy]-7H-furo[3,2-g][1]benzopyran-7-one; (+)-Heraclenin; Prangenin; 9-[[(2R)-3,3-Dimethyloxiranyl]methoxy]-7H-furo[3,2-g][1]benzopyran-7-one; (R)-(+)-9-(2,3-Epoxy-3-methylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one
CAS号:	2880-49-1
分子式:	C₁₆H₁₄O₅
分子量:	286.28
种类:	Standards; Enzyme Activators and Inhibitors; Natural Products;
应用:	Heraclenin inhibits T cell-receptor-mediated proliferation in human primary T cells in a concentration-dependent manner. Heraclenin also induces apoptosis. While imperatorin induces DNA fragmentation at the G1/S phase of the cell cycle, heraclenin induces DNA fragmentation at the G2/M phases of the cell cycle, thus despite a close structural similarity they induce apoptosis in mechanistically different ways.
参考文献	1. Schimmer, O., et al., . Mutagenicity of a furocoumarin epoxide, heraclenin, in Chlamydomonas reinhardii. Mutation research. 169(1-2): 47-50. PMID: 39452362. Abel, G., et al., . Chromosome-damaging effects of heraclenin in human lymphocytes in vitro. Mutation research. 169(1-2): 51-4. PMID: 39452373. Mishra, K C., et al., 1969. Anticoagulant activity of Heraclenin. Indian journal of physiology and pharmacology. 13(3): 153-5. PMID: 53626304. Appendino, Giovanni., et al., 2004. Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin. Journal of natural products. 67(4): 532-6. PMID: 15104479