产品编号：G797850

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	G797850
名称:	GS967
别名:	6-[4-(Trifluoromethoxy)phenyl]-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine; 6-[4-(Trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine; GS 458967
CAS号:	1262618-39-2
分子式:	C₁₄H₇F₆N₃O
分子量:	347.22
种类:	Standards; Enzyme Activators and Inhibitors;
应用:	GS967, also known as GS-458967, is a highly selective late sodium channel current blocker. The selective inhibition of late INa with GS967 can exert antiarrhythmic effects by suppressing EAD- and DAD-mediated extrasystolic activity in PFs and PV and SVC sleeve preparations. Selective late INa inhibition with GS967 exerts potent protective effects against ischemia-induced depolarization and repolarization abnormalities in both atria and ventricles.
参考文献	Belardinelli, Luiz., et al.: J Pharmacol Exp Ther., 344,23(2013); Koltun, Dmitry O., et al.: Bioorg Med Chem Lett., 26,3202(2016)