产品编号：F657735

产品规格：1mg

产品价格：面议

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产品详情

标准品编号:	F657735
名称:	FMK
别名:	1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone; FMK-MEA; Fluoromethylketone-MEA
CAS号:	821794-92-7
分子式:	C₁₈H₁₉FN₄O₂
分子量:	342.37
种类:	Standards; Enzyme Activators and Inhibitors;
应用:	FMK is a potent irreversible RSK1/2 inhibitor (IC50 = 15 nM). Inactivates the C-terminal auto-kinase domain activity. Suppresses RSK2 kinase activity in RSK2-expressing HNSCC cell lines. Reduces HNSCC cell invasive ability. Displays no effect on EGF-stimulated phosphorylation of ERK1 or ERK2.
参考文献	Cohen, Michael S., et al.: Science., 308,1318 (2005); Kang, Sumin., et al.: Cancer Cell., 12,201 (2007); Li, Dan., et al.: J Biol Chem., 288,32528(2013);