产品编号：F596745

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	F596745
名称:	[5-(4-Fluorophenyl)-2-thienyl][2-methyl-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)phenyl]-methanol
分子式:	C₃₂H₃₃FO₁₀S
外观:	白色固体
分子量:	628.66
储存:	冰箱保存
溶解度:	Chloroform, Ethyl Acetate, Methanol
种类:	Standards; Miscellaneous;
应用:	[5-(4-Fluorophenyl)-2-thienyl][2-methyl-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)phenyl]-methanol is an intermediate in the synthesis of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.
参考文献	Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.: Clin. Invest., 1, 145 (2011);