产品编号：F595002
产品规格：2.5mg
产品价格：面议
| 标准品编号: | F595002 |
| 名称: | 5-Fluoroorotic Acid Monohydrate-13C15N2 |
| 别名: | 5-FOVIP(LA)13C15N2 |
| 参考CAS: | 703-95-7未标记 |
| 分子式: | C₄¹³CH₅F¹⁵N₂O₅ |
| 分子量: | 195.08 |
| 种类: | Building Blocks; Isotopic Labeled Analogues; |
| 应用: | 5-Fluoroorotic Acid Monohydrate-13C15N2 is the isotope analog of 5-Fluoroorotic Acid Monohydrate, (5-FOA). 5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloro |
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