产品编号：F591080

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	F591080
名称:	1-[(4-Fluorophenyl)methyl]-2-[4-(4-methyl-1H-pyrazol-1-yl)-1-piperidinyl]-1H-benzimidazole
CAS号:	1186430-60-3
分子式:	C₂₃H₂₄FN₅
分子量:	389.47
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	1-[(4-Fluorophenyl)methyl]-2-[4-(4-methyl-1H-pyrazol-1-yl)-1-piperidinyl]-1H-benzimidazole, is a 2-aminobenzimidazole H1-antihistamines used for the treatment of insomnia. It is also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM.
参考文献	Coon, T. et al.: Bioor. Med. Chem. Lett. Vol.19 P:4380-4384 (2009); Lavrador-Erb K. et al.: Bioorg Med Chem Lett. 2010 May 1;20(9):2916-9.