产品编号：E926747

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	E926747
名称:	6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine
CAS号:	1359873-35-0
参考CAS:	1359873-45-2
分子式:	C₁₄H₁₆N₆S₂
外观:	Off-white Solid
分子量:	332.45
储存:	冰箱保存, under inert atmosphere
溶解度:	Chloroform; Dichloromethane; Methanol;
种类:	Building Blocks; Miscellaneous;
应用:	6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine is an intermediate used in the synthesis of 6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine Hydrochloride (E926745), which is an inhibitor of fusion protein interaction of menin-mixed lineage leukemia (menin-MLL). Menin-MLL inhibitors downregulate the expression of target genes required for MLL fusion protein oncogenic activity and thus effectively reverse MLL fusion protein-mediated leukemic transformation.
参考文献	Grembecka, J. et al.: Nat. Chem. Biol., 8, 277 (2012);