产品编号：E899155

产品规格：2mg

产品价格：面议

---

产品详情

标准品编号:	E899155
名称:	7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin Dihydrochloride
别名:	4-Amino-(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1-Piperidinecarboxylic Acid Ester Dihydrochloride; RPR 132595A Dihydrochloride; NPC (metabolite) Dihydrochloride
参考CAS:	185304-42-1 free amine
分子式:	C₂₈H₃₂Cl₂N₄O₆
外观:	Yellowish Orange Solid
熔点:	>125°C (dec.)
分子量:	591.48
储存:	Amber Vial, -86°C Freezer, Under inert atmosphere
溶解度:	DMSO, Methanol
稳定性:	Hygroscopic
种类:	Standards; Chiral Molecules;
应用:	7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin is a major metabolite of Irinotecan (I767500, HCl trihydrate), a DNA topoisomerase inhibitor.
参考文献	Canal, P., et al.: J. Clin. Oncol., 14, 2688 (1996); Haaz, M., et al.: Cancer Res., 58, 468 (1998); Kehrer, D., et al.: Clin. Cancer Res., 6, 3451 (2000), Hanioka, N., et al.: Xenobiotica, 31, 687 (2001); Satoh, T., et al.: Drug Metab. Dispos., 30, 488 (2002); Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987), Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993)