产品编号：E589090

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	E589090
名称:	α-Epoxyabiraterone Acetate
别名:	(4S,6aR,6bS,8aS,8bR,9aR,10aS,10bR)-6a,8a-Dimethyl-8b-(pyridin-3-yl)-3,4,5,6,6a,6b,7,8,8a,8b,9a,10,10a,10b-tetradecahydro-1H-naphtho[2',1':4,5]indeno[1,2-b]oxiren-4-yl Acetate
分子式:	C₂₆H₃₃NO₃
外观:	白色至白色固体
熔点:	>190°C (dec.)
分子量:	407.55
储存:	Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度:	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
稳定性:	Hygroscopic
种类:	Standards; Chiral Molecules; Steroids; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	α-Epoxyabiraterone Acetate is an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
参考文献	Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)

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