产品编号：E589000
产品规格：5mg
产品价格：面议
| 标准品编号: | E589000 |
| 名称: | Epothilone D (synthetic) |
| 别名: | (4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione; (-)-Desoxyepothilone B; (-)-Epothilone D; 12,13-Deoxyepothilone B; 12,13-Desoxyepothilone B; Desoxyepothilone B; Epo D; Epothilone D; KOS 862; NSC 703147; |
| CAS号: | 189453-10-9 |
| 分子式: | C₂₇H₄₁NO₅S |
| 外观: | 白色固体 |
| 熔点: | 63-66°C |
| 分子量: | 491.68 |
| 储存: | -20°C Freezer |
| 溶解度: | Chloroform (Slightly), DMSO (Slightly) |
| 种类: | Standards; Chiral Molecules; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. |
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