产品编号：E588680

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	E588680
名称:	28-Epirapamycin
别名:	28-epi-Rapamycin; (31S)-Rapamycin
CAS号:	253431-35-5
分子式:	C₅₁H₇₉NO₁₃
外观:	白色固体
熔点:	>120°C (dec.)
分子量:	914.17
储存:	-20°C Freezer
溶解度:	DMSO (Slightly), Methanol (Slightly)
种类:	Standards; Chiral Molecules; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	28-Epirapamycin is an epimer of Rapamycin (R124000), a triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.
参考文献	Yang, W., et. al.: Org. Lett., 1, 2033 (1999); Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977); Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993); Kahan, B.D., et al.: Lancet, 356, 194 (2000); Holmes, D.R., et al.: Circulation, 109, 634 (2004)

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