产品编号：E320300

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	E320300
名称:	EB 47
别名:	5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine; 4-[1-(6-Amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetamide
CAS号:	366454-36-6
分子式:	C₂₄H₂₇N₉O₆
分子量:	537.53
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	EB 47 is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Poly(ADP-ribose) polymerases (PARPs) play a major role in cellular survival and maintenance of energy stores after genotoxic insult.
参考文献	Jagtap, et al.: Bioorg. Med. Chem. Lett., 14, 81 (2004), Gaymes, et al.: Haematologica, 94, 638 (2009), Ferraris, et al.: J. Med. Chem. 53, 4561 (2010),