产品编号：D534910
产品规格：50mg
产品价格：面议
| 标准品编号: | D534910 |
| 名称: | Dorsomorphin Dihydrochloride |
| 别名: | 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine Dihydrochloride; 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine Hydrochloride (1:2) |
| CAS号: | 1219168-18-9 |
| 参考CAS: | Free Base: 866405-64-3 |
| 分子式: | C₂₄H₂₇Cl₂N₅O |
| 外观: | Yellow Solid |
| 熔点: | >228°C(dec.) |
| 分子量: | 472.41 |
| 储存: | Hygroscopic, 冰箱保存, under inert atmosphere |
| 溶解度: | DMSO (Slightly), Water (Slightly) |
| 种类: | Standards; Enzyme Activators and Inhibitors; |
| 应用: | Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53. |
| 参考文献 | |
