产品编号：D487420

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	D487420
名称:	N-[(1S)-1-[[(1R,3S,4S)-3-[6-[9,9-Difluoro-7-[2-[(6S)-5-formyl-5-azaspiro[2.4]hept-6-yl]-1H-imidazol-5-yl]-9H-fluoren-2-yl]-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]hept-2-yl]carbonyl]-2-methylpropyl]-, methyl ester carbamic acid
CAS号:	2040487-30-5
分子式:	C₄₃H₄₃F₂N₇O₄
分子量:	759.84
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	N-[(1S)-1-[[(1R,3S,4S)-3-[6-[9,9-Difluoro-7-[2-[(6S)-5-formyl-5-azaspiro[2.4]hept-6-yl]-1H-imidazol-5-yl]-9H-fluoren-2-yl]-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]hept-2-yl]carbonyl]-2-methylpropyl]-, methyl ester carbamic acid is an impurity of Ledipasvir (L320100), which is most commonly used in combination with sofosbuvir for treatment in chronic hepatitis C genotype 1 patients. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.
参考文献	Lawitz, E., et al.: J. Hepatol., 57, 24 (2012); Afdhal, N., et al.: New England J. Med., 370, 1889 (2014)