产品编号：D480205

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	D480205
名称:	(2S)-N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanyl-2-hydroxy-3-methyl-butanoic Acid
别名:	NSC 668036; N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine-(1S)-1-carboxy-2-methylpropyl Ester
CAS号:	144678-63-7
分子式:	C₂₁H₃₆N₂O₉
分子量:	460.52
种类:	Standards; Enzyme Activators and Inhibitors;
应用:	(2S)-N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanyl-2-hydroxy-3-methyl-butanoic Acid binds the PDZ domain of the Dishevelled (Dvl) protein. It is Wnt signaling inhibitor that inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. (2S)-N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanyl-2-hydroxy-3-methyl-butanoic Acid also suppresses the accumulation of collagen I, α-SMA, and TGF-β1.
参考文献	Shan, J., et al.: Biochemistry. 44, 15495 (2005); Wang, C., et al.: Exp Cell Res. 331, 115 (2015)