产品编号：D474245

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	D474245
名称:	(1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester
别名:	(1R-trans)--4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester; (R)-t-Butyl (3-(hydroxymethyl)cyclopent-2-en-1-yl)carbamate;
CAS号:	168958-19-8
分子式:	C₁₂H₁₉NO₄
分子量:	241.28
储存:	Room Temperature, under inert atmosphere
溶解性:	Methanol
种类:	Building Blocks; Nucleic Acid; Carbohydrates;
应用:	(1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester is an intermediate in synthesizing trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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