产品编号：D472995

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	D472995
名称:	N-[(2R,4R,5S)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-L-phenylalaninamide
别名:	36: PN: WO2005049027 PAGE: 99 claimed sequence; L 458; L 685458; γ-Secretase Inhibitor X
CAS号:	292632-98-5
分子式:	C₃₉H₅₂N₄O₆
外观:	白色固体
熔点:	209-211°C
分子量:	672.85
储存:	冰箱保存
溶解性:	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	N-[(2R,4R,5S)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-L-phenylalaninamide, is a γ-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to generate amyloid β-peptide (Aβ), the major causative agent in Alzheimer disease (AD).
参考文献	Schedin-Weiss, S., et al.: PLoS One, 8, 63962 (2013); Wanngren, J., et al.: J. Bio. Chem., 287, 32640 (2012);