产品编号：D453653

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	D453653
名称:	6,8-Dihydro-8-(methylthio)-7H-pyrrolo[2,3-g]benzothiazol-7-one
别名:	8-(Methylthio)-6H-thiazolo[5,4-e]indol-7(8H)-one
CAS号:	222036-26-2
分子式:	C₁₀H₈N₂OS₂
外观:	Beige Solid
分子量:	236.31
溶解性:	Dichloromethane + Methanol; DMF; DMSO
种类:	Standards; Miscellaneous;
应用:	6,8-Dihydro-8-(methylthio)-7H-pyrrolo[2,3-g]benzothiazol-7-one is an intermediate in synthesizing Imidazolo-oxindole PKR inhibitor C16 (PKR Inhibitor) (P572500). It is a drug which acts as a selective inhibitor of the enzyme double-stranded RNVIP(LA)dependent protein kinase (PKR). It has been shown to effectively inhibit PKR function in vivo and has neuroprotective and nootropic effects in animal studies.
参考文献	Jammi, N., et al.: Biochem. Biophys. Res. Commun., 308, 50 (2003); Ingrand, S., et al.: Neurosci. Lett., 409, 192 (2006); Chen, H., et al.: Eur. J. Neurosci., 28, 2003 (2008); Couturier, J., et al.: J. Biol. Chem., 285, 1272 (2010)