产品编号：D450690

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	D450690
名称:	(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one
CAS号:	1803026-54-1
分子式:	C₁₆H₁₂F₆N₄O
外观:	Light Yellow Oil
分子量:	390.28
溶解性:	Chloroform, DCM, Methanol
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one is an intermediate in the synthesis of 3-Desamino-2,3-dehydro Sitagliptin (D281985),an impurity of Sitagliptin (S491000). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.
参考文献	Kim, D., et al.: J. Med. Chem. 48, 141 (2005); Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005); Bergman, A., et al: Clin. Ther. 28, 55 (2006)