产品编号：D450455

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	D450455
名称:	(1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarbonyl Chloride
别名:	(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinolinecarbonyl Chloride
CAS号:	1195949-26-8
分子式:	C₁₆H₁₄ClNO
外观:	白色固体
分子量:	271.74
溶解性:	Dichloromethane, Ethyl Acetate
种类:	Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarbonyl Chloride is an intermediate in the synthesis of ((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone (P309025). ((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone is a possible impurity of solifenacin (S676700) which is a muscarinic M3 receptor antagoinst. Solifenacin is used in treatment of urinary incontinence.
参考文献	Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)