产品编号：D395155

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	D395155
名称:	2-[[(2,4-Difluorophenyl)methyl]amino]-2-oxo-acetic acid
CAS号:	1248263-78-6
分子式:	C₉H₇F₂NO₃
分子量:	215.15
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	2-[[(2,4-Difluorophenyl)methyl]amino]-2-oxo-acetic acid is an oxidative degradation product of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
参考文献	Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);