产品编号：D297835

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	D297835
名称:	Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant
别名:	(2S,3R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
CAS号:	1185503-48-3
分子式:	C₂₀H₁₈F₇NO₂
分子量:	437.35
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
参考文献	Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998); Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001); Van Belle, S., et al.: Cancer, 94, 3032 (2002); Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006); Gangula, S., et al.: Synthetic Commun., 40, 2254 (2010)