产品编号：D292000

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	D292000
名称:	N-Desmethyl Clozapine
别名:	8-Chloro-11-(1-piperazinyl)-5H-dibenzo[B,E][1,4]diazepine; CLOZAPINE EP IMPURITY C
CAS号:	6104-71-8
分子式:	C₁₇H₁₇ClN₄
外观:	Light Yellow to Yellow Solid
熔点:	>120°C (dec.)
分子量:	312.8
储存:	-20°C Freezer, Under inert atmosphere
溶解性:	Chloroform (Slightly), DMSO, Methanol (Slightly)
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites; Benzodiazepines;
应用:	N-Desmethyl Clozapine is a metabolite of Clozapine (C587500). N-Desmethyl Clozapine is a potent, allosteric agonist at human M1 receptors and is able to potentiate hippocampal NMDA receptor currents through M1 receptor activation.
参考文献	Sur, C., et al.: Proc. Nat. Acad. Sci. U. S. A., 100, 13674 (2003); Kuoppamaki, M. et al.: Eur. J. Pharm. Mol. Pharm. Sect., 245, 179 (1993); Olessen, O.V., et al.: J. Chromatog., 622, 39 (1993); Pirmohamed, M., et al.: J. Pharmacol. Exp. Ther., 272, 984 (1995)

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