产品编号：D291913

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	D291913
名称:	N-Descyclopropylmethyl N-But-3-ene-yl Nalfurafine
别名:	(E)-N-((4R,4aS,7aR,12bS)-3-(But-3-en-1-yl)-4a,9-dihydroxy-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl)-3-(furan-3-yl)-N-methylacrylamide
分子式:	C₂₈H₃₂N₂O₅
分子量:	476.56
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	N-Descyclopropylmethyl N-But-3-ene-yl Nalfurafine is an impurity of Nalfurafine (N255600), a non-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test.
参考文献	Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004), Mori, T., et al.: Life Sci., 75, 2433 (2004), Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006), Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010),