产品编号：D291370

产品规格：1mg

产品价格：面议

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产品详情

标准品编号:	D291370
名称:	Desdimethyl 3-Hydroxy Venetoclax
分子式:	C₄₃H₄₆ClN₇O₈S
分子量:	856.39
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Desdimethyl 3-Hydroxy Venetoclax is a minor human metabolite of ABT 199 (A112430), which is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
参考文献	Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);