产品编号：D291140

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	D291140
名称:	N-Des(4-methylbenzenesulfonamide) 4’-Nitro Tolafentrine
别名:	(10bS)-8,9-Dimethoxy-2-methyl-6-(4-nitrophenyl)-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridine; cis-1,2,3,4,4a,10b-Hexahydro-8,9-dimethoxy-2-methyl-6-(4-nitrophenyl)-benzo[c][1,6]naphthyridine
CAS号:	35134-99-7
分子式:	C₂₁H₂₃N₃O₄
外观:	Yellow Solid
分子量:	381.43
溶解性:	Dichloromethane(Partial), Dimethylformamide, Methanol
种类:	Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	N-Desmethylbenzenesulfonamide 4’-Nitro Tolafentrine is an intermediate in the synthesis of Tolafentrine (T531000), which is a dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension.
参考文献	Huxtable, R., et al.: Pharmacol. Ther., 47, 371 (1990), Tanaka, K., et al.: Cancer Res., 55, 2927 (1995), Wagner, R., et al.: J. Pharmacol. Exp. Ther., 282, 1650 (1997), Cowan, K., et al.: Nat. Med., 6, 698 (2000), Shankavaram, U., et al.: J. Biol. Chem., 276, 19027 (2001),