产品编号：D230795

产品规格：500mg

产品价格：面议

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产品详情

标准品编号:	D230795
名称:	Demecolcine Hydrobromide Salt
别名:	N-Desacetyl-N-methylcolchicine Hydrobromide Salt; (7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one Hydrobromide;
CAS号:	1246817-95-7
参考CAS号:	freebase: 477-30-5
分子式:	C₂₁H₂₆BrNO₅
外观:	淡黄色固体
熔点:	224-229°C
分子量:	452.34
储存:	冰箱保存
溶解性:	Dichloromethane, DMSO, Methanol
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
参考文献	Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),