产品编号：D288245

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	D288245
名称:	Desethyl Sacubitril
别名:	[S-(R*,S*)]-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-Biphenyl]-4-pentanoic Acid; (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic Acid; (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic Acid; Sacubitrilat; LBQ 657
CAS号:	149709-44-4
分子式:	C₂₂H₂₅NO₅
外观:	白色至白色固体
熔点:	166-168°C
分子量:	383.44
储存:	冰箱保存
溶解性:	DMSO (Slightly), Methanol (Slightly)
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Desethyl Sacubitril is an impurity in the synthesis of Sacubitril (S080895), an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
参考文献	McMurray, J., et al.: N. Eng. J. Med., 371 (2014);