产品编号：D230465

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	D230465
名称:	1-Demethylcolchicine
别名:	1-Demethylcolchicine; Benzo[a]heptalene Acetamide Derivative; (-)-1-Demethylcolchicine; 1-Demethylcolchicine; Demethyl-colchicine
CAS号:	3464-68-4
分子式:	C₂₁H₂₃NO₆
分子量:	385.41
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	1-Demethylcolchicine is a derivative of Colchicine (C640000) an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
参考文献	Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),