产品编号：D228795

产品规格：1mg

产品价格：面议

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产品详情

标准品编号:	D228795
名称:	3-Des-(4-fluorophenyl) 3-(4-Fluorobiphen-3-yl) Aprepitant
分子式:	C₂₉H₂₅F₇N₄O₃
分子量:	610.52
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	3-Des-(4-fluorophenyl) 3-(4-Fluorobiphen-3-yl) is a derivative of Aprepitant (A729800), which is a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
参考文献	Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Van Belle, S., et al.: Cancer, 94, 3032 (2002), Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006)