产品编号：D228715

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	D228715
名称:	Defluoro Dolutegravir
别名:	(4R,12aS)-N-(4-Fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;
CAS号:	1863916-88-4
分子式:	C₂₀H₂₀FN₃O₅
外观:	白色固体
熔点:	>166°C (dec.)
分子量:	401.39
储存:	-20°C Freezer
溶解性:	DMSO (Slightly), Methanol (Slightly, Heated)
种类:	Standards; Enzyme Activators and Inhibitors;
应用:	Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
参考文献	Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);