产品编号：D198195

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	D198195
名称:	N-Deacetyl-1,2,3,10-demethyl Colchicine Hydrobromide
别名:	(S)-7-Amino-6,7-dihydro-1,2,3,9-tetrahydroxy-,benzo[a]heptalen-10(5H)-one, Hydrobromide
CAS号:	152242-11-0
参考CAS号:	Free Base: 134568-35-7
分子式:	C₁₆H₁₅NO₅•HBr
分子量:	301.298091
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	N-Deacetyl-1,2,3,10-demethyl Colchicine Hydrobromide is a derivative of Colchicine (C640000) an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
参考文献	Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),