产品编号：D126860

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	D126860
名称:	3,17-Diiodoandrosta-3,5,16-triene
别名:	(8R,9S,10R,13S,14S)-3,17-Diiodo-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthrene; 3,17-Diiodo-androst-3,5,16-triene
CAS号:	1268610-38-3
分子式:	C₁₉H₂₄I₂
分子量:	506.2
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	3,17-Diiodoandrosta-3,5,16-triene is used in the synthesis of 3,17-Dicarboxamido-androst-3,5,16-triene via palladium-catalyzed aminocarbonylation. It is an Abiraterone 3-iodine impurity. Abiraterone is a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
参考文献	Acs, Peter., et al.: Steroids, 76, 280(2011); Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389 (2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005);