产品编号：C992518

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	C992518
名称:	17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methylbenzylamino)morphinan
别名:	(4R,4aS,7R,7aR,12bS)-7-(Cenzyl(methyl)amino)-3-(cyclopropylmethyl)-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol; Nalfurafine Impurity;
CAS号:	162819-83-2
分子式:	C₂₈H₃₄N₂O₃
分子量:	446.58
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methylbenzylamino)morphinan is an impurity of Nalfurafine (N255600), the first in class non-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test.
参考文献	Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004), Mori, T., et al.: Life Sci., 75, 2433 (2004), Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006), Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010),