产品编号：C987390

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	C987390
名称:	6-Cyano-2-[1-[4-ethyl-3-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-1-methylethyl]-1H-indole-3-carboxylic Acid
CAS号:	1256584-78-7
分子式:	C₃₀H₃₆N₄O₃
分子量:	500.63
类别:	Standards; Molecular Biology; Enzyme Activators and Inhibitors;
应用:	6-Cyano-2-[1-[4-ethyl-3-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-1-methylethyl]-1H-indole-3-carboxylic Acid is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.
参考文献	Jiang, X. et al.: Eur. J. Med. Chem., 105, 39 (2015); Sakamoto, H., et al.: Cancer Cell., 19, 679 (2011); Kinoshita, K., et al.: Bio-org. Medn., 20, 1271 (2012);