产品编号：C882955

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	C882955
名称:	3-Cyclobutoxy-4-(difluoromethoxy)benzoyl Chloride
分子式:	C₁₂H₁₁ClF₂O₃
分子量:	276.66
类别:	Building Blocks; Miscellaneous;
应用:	3-Cyclobutoxy-4-(difluoromethoxy)benzoyl Chloride is an intermediate for the synthesis of O-Des(Cyclopropylmethyl) O-cyclobutyl Roflumilast (C982940), which is an intermediate used in the synthesis of Roflumilast (R639700). Roflumilast is a selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; used in treatment of chronic obstructive pulmonary disease.
参考文献	Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001); Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001); Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002); Rabe, K.F., et al.: Lancet, 366, 563 (2005)