产品编号：C781800
产品规格：10mg
产品价格：面议
| 标准品编号: | C781800 |
| 名称: | Crenolanib Trifluoroacetic Acid Salt |
| 别名: | 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine Trifluoroacetic Acid Salt; ARO 002 Trifluoroacetic Acid Salt; CP 868596 Trifluoroacetic Acid Salt; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine Trifluoroacetic Acid Salt; |
| CAS号: | 1797008-57-1 |
| 参考CAS: | Free amine: 670220-88-9 |
| 分子式: | C₂₈H₃₀F₃N₅O₄ |
| 外观: | 白色至淡黄色固体 |
| 熔点: | 214-217°C |
| 分子量: | 557.56 |
| 储存: | 冰箱保存 |
| 溶解度: | DMSO (Slightly), Methanol (Very Slightly) |
| 类别: | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | Crenolanib (CP-868569) is a tyrosine kinase inhibitor that acts by specifically inhibiting the receptor tyrosine kinases PDGFRα and PDGFRβ. Crenolanib (CP-868569) inhibits the activity of PDGFRα D842V kinase and prevented the phosphorylation of wild type PDGFRα. Crenolanib (CP-868569) possesses potential antineoplastic activity. Crenolanib is believed to suppress PDGFR-related signal transduction pathways leading to the inhibition of tumor angiogenesis and tumor cell proliferation. |
| 参考文献 | |
