产品编号：C781250

产品规格：10mg

产品价格：面议

---

产品详情

标准品编号:	C781250
名称:	CP-100356 Hydrochloride
别名:	4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine Monohydrochloride;
CAS号:	142715-48-8
参考CAS:	142716-85-6-free base
分子式:	C₃₁H₃₇ClN₄O₆
外观:	白色至Light Tan Solid
熔点:	206-210°C
分子量:	597.1
储存:	冰箱保存
溶解度:	Chloroform (Slightly), Methanol (Slightly)
类别:	Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM).
参考文献	Ayrton, A., et al.: Xenobiotica, 31, 469 (2001), Mizuno, N., et al.: Pharmacol. Rev., 55, 425 (2003), Fojo, T., et al.: Clin. Breast Cancer, 7, 749 (2007), Polli, J., et al.: Drug Metab. Dispos., 36, 695 92008),

Download MSDS File