产品编号：C441300

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	C441300
名称:	Ciliobrevin A
别名:	2,4-Dichloro-α-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile; HPI-4;
CAS号:	302803-72-1
分子式:	C₁₇H₉Cl₂N₃O₂
分子量:	358.18
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Ciliobrevin A is a Hedgehog pathway inhibitor; ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics. Ciliobrevin A inhibited proliferation of cerebellar granula neuron precursor cells, an important model of HH signaling.
参考文献	Heald, R., et al.: Nature, 382, 420 (1996), Gaglio, T., et al.: J. Cell Biol., 138, 1055 (1997), Zhu, G., et al.: J. Med. Chem., 49, 2063 (2006), Varma, D., et al.: J. Cell Biol., 182, 1045 (2008),