产品编号：C429220

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	C429220
名称:	(2S,3S,4S,5R,6S)-Benzyl 6-(2-(1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indol-3-yl)acetoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate
分子式:	C₃₁H₂₈ClNO₁₀
分子量:	610.01
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(2S,3S,4S,5R,6S)-Benzyl 6-(2-(1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indol-3-yl)acetoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate is an intermediate in the synthesis of 1-​[1-​(4-​Chlorobenzoyl)​-​5-​hydroxy-​2-​methyl-​1H-​indole-​3-​acetate]β-​D-​Glucopyranuronic Acid (C429115), which is an analog of Indomethacin Acyl-β-D-glucuronide a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.
参考文献	Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995), Gamage, N., et al.: Toxicol. Sci., 90, 5 (2006), Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (2007), Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (2008),